Factor V Leiden Mutation - an Unusual Cause of Hypopituitarism?
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Abstract
ABSTRACT
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary failure. She was initially diagnosed as Sheehan's syndrome in 1974 and Takayasu arteritis in 1990. But she was found to be positive for factor V Leiden mutation in 1990. We suggest that this mutation, which causes resistance to activated protein C and is an established risk factor for thrombosis, also is the cause for both the ischemic necrosis of the pituitary and subclavian artery occlusion in our case.
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary failure. She was initially diagnosed as Sheehan's syndrome in 1974 and Takayasu arteritis in 1990. But she was found to be positive for factor V Leiden mutation in 1990. We suggest that this mutation, which causes resistance to activated protein C and is an established risk factor for thrombosis, also is the cause for both the ischemic necrosis of the pituitary and subclavian artery occlusion in our case.